Table 1.

Correlation between the Foxp3 expression and clinicopathological characteristics of OSCC

Clinical pathological feature	N	Expression of Foxp3
		Stain value = 1	Stain value = 2	Stain value = 3	P Value
		N = 99	N = 106	N = 68
Age					0.65
<60	133	51 (38.3 %)	49 (36.9 %)	33 (24.8 %)
≥60	140	48 (34.3 %)	57 (40.7 %)	35 (25.0 %)
Sex					0.29
Male	188	63 (33.5 %)	74 (39.4 %)	51 (27.1 %)
Female	85	36 (42.4 %)	32 (37.6 %)	17 (20.0 %)
Smoking					0.84
Yes	132	47 (35.6 %)	50 (37.9 %)	35 (26.5 %)
No	141	52 (36.9 %)	56 (39.7 %)	33 (23.4 %)
Drinking					0.47
Yes	131	45 (34.4 %)	49 (37.4 %)	37 (28.2 %)
No	142	54 (38.0 %)	57 (40.1 %)	31 (21.9 %)
Differentiation					0.30
High	200	73 (36.5 %)	82 (41.0 %)	45 (22.5 %)
Medium	64	23 (35.9 %)	22 (34.4 %)	19 (29.7 %)
Low	9	3 (33.3 %)	2 (22.2 %)	4 (44.5 %)
Tumor site					0.23
Gingiva	52	16 (30.8 %)	19 (36.5 %)	17 (32.7 %)
Tongue	131	50 (38.1 %)	47 (35.9 %)	34 (26.0 %)
Buccal	61	26 (42.6 %)	24 (39.4 %)	11 (18.0 %)
Othersa	29	7 (24.1 %)	16 (55.2 %)	6 (20.7 %)
T stage					0.63
T1-T2	186	68 (36.5 %)	74 (39.8 %)	44 (23.7 %)
T3-T4	87	31 (35.6 %)	32 (36.8 %)	24 (27.6 %)
N stage					0.000***
N0	183	73 (39.9 %)	82 (44.8 %)	28 (15.3 %)
N1-N3	90	26 (28.9 %)	24 (26.7 %)	40 (44.4 %)
Clinical Stage					0.09
I-II	142	55 (38.8 %)	59 (41.5 %)	28 (19.7 %)
III-IV	131	44 (33.6 %)	47 (35.9 %)	40 (30.5 %)

Stain value = 1, low level of Foxp3 expression; Stain value = 2, medium level of Foxp3 expression; Stain value = 3, high levels of Foxp3 expression

^aOthers included include hard palate, oropharynx and lips

P value was determined using the Linear-by-Linear Association test. *,P<0.05;**, P<0.01;***, P<0.001