Table 4.
Tissue-specifically expressed subsets of genes in relevant human tissuesa
| Protein sets tested and expression sets used (columns) Tissue types (rows) | NQ-rich proteinsb | Prion predictions by PLAACb | Prion predictions by PAPAb | DISORDERED PROTEINS (>70 % set)b | ||||
|---|---|---|---|---|---|---|---|---|
| GXA Illumina body map expression library | Specond | GXA Illumina body map expression library | Specond | GXA Illumina body map expression library | Specond | GXA Illumina body map expression library | Specond | |
| Brain | 38/1966 (1.9 %, N.S.) | 9/503 (1.8 %, N.S.) | 10/1966 (0.5 %, N.S.) | 3/503 (0.6 %, N.S.) | 25/1966 (1.3 %, N.S.) | 8/503 (1.6 %, N.S.) | 127/1966 (6.5 %, N.S.) | 42/503 (8.4 %, N.S.) |
| Spinal Cord | N/A | 3/262 (1.1 %, N.S.) | N/A | 2/262 (1.1 %, N.S.) | N/A | 3/262 (1.1 %, N.S.) | N/A | 31/262 (11.8 %, P = 0.001) |
| Skeletal Muscle | 25/ 753 (3.3 %, P = 0.015) | 5/270 (1.9 %, N.S.) | 6/753 (0.8 %, N.S.) | 3/270 (1.1 %, N.S.) | 4/753 (0.5 %, N.S.) | 4/270 (1.5 %, N.S.) | 52/752 (7.0 %, N.S.) | 19/270 (7.0 %, N.S.) |
aEnrichments are in bold type. For each is listed the fraction, with the percentage and hypergeometric P-value in brackets (N.S. = not significant)
bFor NQ-rich proteins, the LPS threshold used is 1e-10 (overall fraction is 414/22699, 1.8 %). The PLAAC and PAPA predictions use default values (overall fractions: 136 / 22699 (0.6 %) PLAAC; 279 / 22699 (1.2 %) PAPA). In all cases, human protein composition is used for these annotations. The disordered proteins are annotated as described in Methods