Table 2.

Plasma pharmacokinetic parameters of MCHB and CNOB in mice carrying 4T1/HchrR6 tumors. Plasma samples were collected at various times (5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, 12 h, and 24 h) after iv dose of CNOB in nude mice carrying 4T1/HchrR6 tumors. MCHB and CNOB levels overtime were determined by LC/MS/MS

CNOB Dose	Analyte	Cmax ± SE	AUC0-24 ± SE	Vss	CL	t1/2
mg/kg		ng/mL	h*ng/mL	L/kg	L/h/kg	h
3.3	CNOB	141 ± 28.6	166 ± 23.5	81.5	17.7	4.6
	MCHB	145 ± 30.4	148 ± 16.0	117	21.1	8.3

C _max maximum observed concentration ± standard error (SE), AUC _0-24 area under the concentration curve from 0 to 24 h ± SE, V _ss volume of distribution, CL clearance; t _1/2 terminal elimination half-life