Fig. 4.

Effects of PF, MK-801, and NBQX on EAA agonist-induced biting and scratching behavior in mice. a: treatment with PF + MK-801 on glutamate-induced behavior; b: treatment with PF + MK-801 on NMDA-induced behavior; c: treatment with PF + MK-801 or PF + NBQX on AMPA-induced behavior. PF (100, 200, 500 nmol, i.c.v.) was administered 15 min before excitatory amino acid injection. MK-801 (MK 14.8 pmol, i.t.) and NBQX (5 nmol, i.t.) were administered 5 min before excitatory amino acid injection. The control group received ACSF. The time spent on biting or scratching induced by excitatory amino acids during the first 2 min was recorded. Data represent mean ± S.E. (n = 12). ^* p < 0.05, ^*** p < 0.001 compared with the control group; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 compared with the MK-treated group, respectively