Fig. 7.

Effects of PF and antisense ODN subunits of NMDA receptor on the NMDA-induced biting and scratching behavior in mice. a: The time course effect of antisense ODNs on 1, 3, 7 days. Antisense ODNs: NR1, NR2A, NR2B, NR2C (15nM, i.c.v.) were administered 1, 3, 7 days before NMDA (122 pmol, i.t.). b: The effects of 2B and 2B combined with PF on biting and scratching behavior in NMDA-treated mice. PF 100, 200, 500 nmol, i.c.v.) were administered 15 min before of NMDA. Antisense ODNs (15 nM, i.c.v.) were administered 1, 3, 7 days before NMDA administration. The time spent on biting or scratching behavior during the first 2 min after NMDA administration was recorded. Data are shown as mean ± S.E. (n = 12). ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001 compared with the NMDA group; ^# P < 0.05, ^## P < 0.01, ^### P < 0.001 compared with the antisense 2B group, respectively