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. 2016 Jul 25;11:66. doi: 10.1186/s13000-016-0519-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Patient 1 (a–c). a: A diffuse infiltrate of small to medium-sized atypical lymphocytes and many atypical IELs are seen in the duodenal (a) and cecal (b) mucosa. c: Small intraepithelial lymphocytes are scattered in the non-neoplastic ascending colonic mucosa, indicating lymphocytic colitis. Patient 2 (d, e). d: Duodenal enteropathy with atrophic villi and increased IELs. e: Many small CD8-positive IELs are seen in the duodenum (a, b, c, d: H&E stain; e: immunohistochemistry, hematoxylin stain)