FIG. 1.

PUFAs are metabolized by P450 enzymes with epoxygenase activity/sEH (P450/sEH), LOX, COX, or nonenzymatic autoxidation pathways to a number of oxylipins. Only oxylipins analyzed in this study are shown (see Supplementary Tables S6–S9 for a complete summary). ^aLTB4s include LTB4, 6-trans-LTB4, 20-OH-LTB4 and 20-COOH-LTB4. Abbreviations: DiHDPE, dihydroxy-docosapentaenoic acid; DiHETE, dihydroxy-eicosatetraenoic acid; DiHOME, dihydroxy-octadecenoic acid; DiHODE, dihydroxy-octadecadienoic acid; DiHETrE, dihydroxy-eicosatrienoic acid; EKODE, epoxy-keto-octadecenoic acid; EpDPE, epoxy-docosapentaenoic acid; EpETE, epoxy-eicosatetraenoic acid; EpETrE, epoxy-eicosatrienoic acid; EpODE, epoxy-octadecadienoic acid; EpOME, epoxy-octadecenoic acid; HDoHE, hydroxyl-DHA; HEPE, hydroxy-eicosapentaenoic acid; HETE, hydroxyl-eicosatetraenoic acid; 15(S)-HETrE, hydroxy-trienoic acid; 9-HODE, 9-hydroxy-10,12-octadecadienoic acid; HOTrE, hydroxy-octadecatrienoic acid; 6-keto-PGF1a, 6-keto-prostaglandin F1a; LTB, leukotriene B; LXA4, lipoxin A4; oxo-ETE, oxo-eicosatetraenoic acid; PGE, prostaglandin E; THF-diol, tetrahydrofurandiol; TXB, thromboxane B.