FIG. 4.

Increasing PCB 126 doses resulted in an increase in (A) total hepatic P450 content, (B) EROD activity in liver microsomes as well as sEH activity in (C) cytosol, and (D) peroxisomes relative to controls. Rats were treated every 2 weeks with i.p. injections of corn oil (vehicle) or PCB 126 in corn oil for 3 months; see Table 1 for details regarding the doses. Data are expressed relative to controls because subcellular fractions were generated from frozen tissue samples and are presented as the mean ± SEM. Dunnett’s multiple testing correction procedure was used to compare PCB 126 treatment with the corn oil control. *P < .05; **P < .01; ***P < .001.