FIG. 8.

The epoxide-to-diol metabolite ratios decreased in a dose-dependent manner in plasma from PCB 126-treated male rats for several oxylipins, as determined by metabolomics profiling with liquid chromatography-tandem mass spectrometry. Shown are representative examples of epoxide-to-diol ratios of oxylipins derived from (A) ARA, (B) LA, (C) DHA, and (D) EPA. See Supplementary Table S10 for a complete summary of epoxide-to-diol ratios. Data are presented as the mean ± SEM (n = 10 for control or n = 8 for PCB treatment groups). Dunnett’s multiple testing correction procedure was used to compare PCB 126 treatment with the corn oil control. Significantly different from control *P < .05; ***P < .001.