TABLE 1.
Group | Number of Rats | PCB 126 Dose/Injection |
TCDD TEQb Dose/Injection |
Cumulative PCB126 Dose |
Cumulative TCDD TEQb Dose |
||||
---|---|---|---|---|---|---|---|---|---|
µmol/kg b.w. | µg/kg b.w. | nmol/kg b.w. | µg/kg b.w. | µmol/kg b.w. | µg/kg b.w. | nmol/kg b.w. | µg/kg b.w. | ||
Vehicle (corn oil) | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low dose | 8 | 0.01 | 3.3 | 1 | 0.33 | 0.06 | 19.8 | 6 | 1.98 |
Medium dose | 8 | 0.05 | 16.3 | 5 | 1.63 | 0.3 | 97.8 | 30 | 9.78 |
High dose | 8 | 0.2 | 65 | 20 | 6.5 | 1.2 | 390 | 120 | 39 |
aAnimals were acclimatized to the animal facility for 1 week, randomized into the 4 treatment groups, and treated every 2 weeks with i.p. injections of corn oil (vehicle; 5 mL/kg b.w.) or PCB 126 in corn oil (5 mL/kg b.w.) for 3 months.
bThe PCB 126 dose, expressed as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) toxic equivalent quotient, was calculated using the 2005 WHO TEF of PCB 126 of 0.1 (Van den Berg et al., 2006).