Table 3.
Pro-apoptotic pathway genes that were upregulated by >1.5 fold in embryos exposed to 400 mg/kg hydroxyurea.
| Gene symbol | Gene name | Fold change | P-value |
|---|---|---|---|
| Fas | Fas cell surface death receptor | 10.99 | .0002 |
| Tnfrsf10a | Tumor necrosis factor receptor superfamily, member 10a | 4.99 | .0002 |
| Apaf1 | Apoptotic peptidase activating factor 1 | 3.90 | .0003 |
| Bbc3 | BCL2 binding component 3 | 2.73 | .0007 |
| Casp7 | Caspase 7, apoptosis-related cysteine peptidase | 2.26 | .0008 |
| Bik | BCL2-interacting killer (apoptosis-inducing) | 1.92 | .0011 |
| Dapk1 | Death-associated protein kinase 1 | 1.89 | .0037 |