Table 4.
P53 signaling pathway genes that were upregulated by >1.5-fold in embryos exposed to 400 mg/kg hydroxyurea.
| Gene symbol | Gene name | Fold change | P-value |
|---|---|---|---|
| Cdkn1a | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12.70 | .0009 |
| Fas | Fas cell surface death receptor | 10.99 | .0002 |
| Tp53inp1 | Tumor protein p53 inducible nuclear protein 1 | 9.32 | .0001 |
| Ccng1 | Cyclin G1 | 9.17 | .0000 |
| Tnfrsf10a | Tumor necrosis factor receptor superfamily, member 10a | 4.99 | .0002 |
| Apaf1 | Apoptotic peptidase activating factor 1 | 3.90 | .0003 |
| Pidd1 | p53-induced death domain protein 1 | 3.35 | .0010 |
| Bbc3 | BCL2 binding component 3 | 2.73 | .0007 |
| Pml | Promyelocytic leukemia | 2.50 | .0011 |
| Rb1 | Retinoblastoma 1 | 2.40 | .0008 |
| Perp | PERP, TP53 apoptosis effector | 1.77 | .0008 |
| Gadd45a | Growth arrest and DNA-damage-inducible, alpha | 1.76 | .0017 |
| Atm | ATM serine/threonine kinase | 1.57 | .0010 |
| Kat2b | K(lysine) acetyltransferase 2B | 1.56 | .0034 |