Table 5.
Top predicted activated upstream regulators in GD 9 embryos exposed to 400 mg/kg hydroxyurea by descending P-value order.
| Upstream regulator | Molecule type | Predicted activation state | Activation z-score | P-value of overlap |
|---|---|---|---|---|
| TP53 | Transcription regulator | Activated | 5.74 | 3.12E−23 |
| BRCA1 | Transcription regulator | Activated | 3.17 | 5.49E−10 |
| CCND1 | Transcription regulator | – | 0.63 | 5.09E−09 |
| CDKN1A | Kinase | – | 0.11 | 2.81E−08 |
| TP63 | Transcription regulator | Activated | 3.49 | 4.78E−08 |
| TOPBP1 | Other | – | −1.89 | 1.54E−07 |
| TP73 | Transcription regulator | Activated | 3.01 | 1.69E−07 |
| IGF1 | Growth factor | – | 1.68 | 2.77E−07 |
| PTH | Other | – | 0.69 | 3.75E−07 |