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Schema of upstream and downstream signaling pathways of mTORC1. mTORC1 has several upstream pathways. Note that Rheb is a direct upstream component and 4E-BP1 and S6 are downstream components of the mTORC1 signaling pathway. GTP-bound Rheb activates mTORC1 and contributes to the phosphorylation of 4E-BP1 and S6
