Figure 2.

Electrophysiology of normal and OA sfMPCs. Voltage clamp data from normal (n = 29 from 2 patients) and OA (n = 22 from 2 patients). The inward rectifying current was active in 79% of normal cells and 54% of OA cells. (A) Representative example of the current ramp seen in cells expressing functional inward rectifier channels before and after 70 mM potassium solution was added. (B) Inward current density was lower in OA cells than in normal cells (*p < 0 .05) (C) Outward current density decreased 38%with the addition of TEA in both cell lines lines. (D) The resting potential and cell capacitance (E) of each line was not significantly changed.