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. 2015 Dec 8;10(2):158–166. doi: 10.1080/19336950.2015.1120390

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Effects of S2-S3 linker mutations on use-dependent activation. Use-dependent activation of a panel of S2-S3 linker mutations was quantified using trains of repetitive depolarizations (20 Hz) from −80 mV (40 ms) to +60 mV (10 ms), as described in Figure 1A. Each data point represents the extent of use-dependent activation observed in a single cell. Prominent use-dependence was observed with Thr, Val, Ser, or Met in position 252 (n = 15–26 for each construct).