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. 2015 Dec 8;10(2):158–166. doi: 10.1080/19336950.2015.1120390

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 6. — Comparison of peak current to use-dependent activation in Kv1.2, Kv1.2[T252S] and Kv1.2[T252V]. (A) Relationship between peak current and % use-dependent activation, with each data point representing the current magnitude and use-dependence for a single cell. Data points distinguish between cells transfected with Kv1.2 (black circles) vs. cells transfected with Kv1.2 plus siRNA oligonucleotides (white circles). Exemplar traces illustrating pronounced use-dependence in a cell with small currents (top, co-transfected with siRNA), and weak use-dependence in a cell with large currents (bottom) are shown. Similar data were collected for Thr252 mutants that retain sensitivity to use-dependent activation: (B) Kv1.2[T252V], and (C) Kv1.2[T252S].