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Chronic ocular hypertension (OHT) was induced in both BDNF_ overexpression (OE) and control mice. (A) Laser illumination and microbead injection was performed in the right eyes (OHT) while the untreated left eyes of the same mice were used as controls. IOP was measured at 1 month (m), 2 months, and 3 to 5 months post surgery. (B) Retinal BDNF level in OHT eyes was reduced in control mice but remained upregulated in BDNF_OE mice. **P < 0.01 in Student's t-test.
