Table 3.
Significant differences in the nodal closeness centrality between groups (FDR-corrected)
| Region | CTR | sMCI | P value |
|---|---|---|---|
| Lh Posterior cingulate | 0.30 | 0.48 | 0.001 |
| Lh Hippocampus | 1 | 0.29 | 0.001 |
| Lh Amygdala | 1 | 0.34 | 0.001 |
| Rh Pericalcarine | 0.38 | 0.28 | 0.001 |
| Rh Hippocampus | 1 | 0.38 | 0.001 |
| Rh Amygdala | 1 | 0.33 | 0.001 |
| CTR | lMCIc | ||
| Lh Pallidum | 0.39 | 1 | 0.001 |
| Lh Hippocampus | 1 | 0.39 | 0.001 |
| Lh Amygdala | 1 | 0.34 | 0.001 |
| Rh Insula | 0.28 | 0.53 | 0.001 |
| Rh Pericalcarine | 0.38 | 0.30 | 0.001 |
| Rh Temporal pole | 0.29 | 0.46 | 0.001 |
| Rh Entorhinal | 0.22 | 0.45 | 0.001 |
| Rh Hippocampus | 1 | 0.44 | 0.001 |
| Rh Amygdala | 1 | 0.33 | 0.001 |
| CTR | eMCIc | ||
| Lh Posterior cingulate | 0.30 | 0.54 | 0.001 |
| Lh Lingual G | 0.43 | 0.56 | 0.001 |
| Lh Temporal pole | 0.39 | 0.49 | 0.001 |
| Lh Hippocampus | 1 | 0.26 | 0.001 |
| Lh Amygdala | 1 | 0.35 | 0.001 |
| Lh Accumbens | 0.36 | 1 | 0.001 |
| Rh Insula | 0.28 | 0.49 | 0.001 |
| Rh Temporal pole | 0.29 | 0.45 | 0.001 |
| Rh Entorhinal | 0.22 | 0.46 | 0.001 |
| Rh Hippocampus | 1 | 0.32 | 0.001 |
| Rh Amygdala | 1 | 0.32 | 0.001 |
| Rh Accumbens | 0.54 | 1 | 0.001 |
| CTR | AD | ||
| Lh Insula | 0.38 | 0.51 | 0.001 |
| Lh Posterior cingulate | 0.30 | 0.55 | 0.001 |
| Lh Entorhinal | 0.29 | 0.44 | 0.001 |
| Lh Hippocampus | 1 | 0.31 | 0.001 |
| Lh Amygdala | 1 | 0.31 | 0.001 |
| Rh Lateral orbitofrontal G | 0.47 | 0.58 | 0.006 |
| Rh Insula | 0.28 | 0.53 | 0.001 |
| Rh Entorhinal | 0.22 | 0.44 | 0.001 |
| Rh Hippocampus | 1 | 0.31 | 0.001 |
| Rh Amygdala | 1 | 0.31 | 0.001 |
| sMCI | lMCIc | ||
| Lh Postcentral G | 0.41 | 0.58 | 0.005 |
| Lh Pallidum | 0.21 | 1 | 0.001 |
| Rh Postcentral | 0.41 | 0.61 | 0.001 |
| sMCI | eMCIc | ||
| Lh Pericalcarine | 0.26 | 0.41 | 0.001 |
| Lh Transverse temporal G | 0.40 | 0.54 | 0.001 |
| Lh Accumbens | 0.21 | 1 | 0.001 |
| Rh Lingual G | 0.32 | 0.50 | 0.001 |
| Rh Accumbens | 0.21 | 1 | 0.001 |
| sMCI | AD | ||
| Lh Postcentral G | 0.41 | 0.60 | 0.001 |
| Lh Pallidum | 0.21 | 1 | 0.001 |
| Rh Pericalcarine | 0.28 | 0.37 | 0.001 |
| Rh Pallidum | 0.21 | 1 | 0.001 |
| lMCIc | eMCIc | ||
| Lh Accumbens | 0.30 | 1 | 0.001 |
| eMCIc | AD | ||
| Lh Lingual | 0.55 | 0.43 | 0.001 |
| Rh Frontal pole | 0.34 | 0.45 | 0.001 |
Note: CTR, controls; sMCI, stable mild cognitive impairment; lMCIc, late mild cognitive impairment converters; eMCIc, early mild cognitive impairment converters; AD, Alzheimer's disease; Lh, left hemisphere; Rh, right hemisphere; G, gyrus.