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. Author manuscript; available in PMC: 2016 Jul 26.
Published in final edited form as: Biol Psychiatry. 2010 Jan 1;67(1):85–87. doi: 10.1016/j.biopsych.2009.08.015

Figure 1.

Figure 1

Extinction of naloxone-induced conditioned place aversion in morphine-dependent rats. A. Rats implanted with morphine pellets exhibit conditioned place aversion (CPA) to an environment previously paired with a low dose of naloxone (15 μg/kg), whereas animals implanted with blank (placebo) pellets do not. B. The magnitude of CPA in morphine-dependent rats declines following repeated confinements in the previously naloxone-paired environment in the absence of acute withdrawal. C. Morphine-dependent rats not exposed to the previously naloxone-paired environment in the absence of withdrawal exhibit persistent CPA. *p< .05, ** indicates p< .01 vs. blank pellet, Scheffé test.