Table.
Blood values and functional hemostatic assays.
| Measurement | Baseline | Heat stress | LBNP | Recovery | P1 |
|---|---|---|---|---|---|
| PaO2 (kPa) | 13.7 (13.1–14.1) | 15.6 (15.1–15.9)* | 16.6 (15.7–18.4)* | 12.9 (11.8–14.2)†,‡ | P = 0.009 |
| PaCO2 (kPa) | 5.4 (5.2–5.5) | 4.6 (3.6–4.8)* | 3.6 (3.3–3.9)*,† | 5.2 (4.7–5.5)*,‡ | P = 0.001 |
| Hematocrit (ratio) | 0.41 (0.41–0.43) | 0.42 (0.41–0.45)* | 0.43 (0.43–0.44)* | 0.42 (0.41–0.44)*,‡ | P < 0.001 |
| Platelet count (109* L−1) | 214 (201–255) | 231 (221–277)* | 248 (241–298)*,† | 225 (211–272)*,‡ | P < 0.001 |
| Leukocytes (109* L−1) | 4.7 (4.5–5.6) | 5.4 (5.3–6.0)* | 6.5 (5.7–7.9)*,† | 5.3 (5.0–6.4)*,‡ | P < 0.001 |
| aPTT (s) | 31 (28–32) | 30 (27–31)* | 28 (26–30)* | 28 (25–30)*,† | P < 0.001 |
| INR | 1.2 (1.1–1.2) | 1.1 (1.1–1.2) | 1.1 (1.1–1.2) | 1.1 (1.1–1.2) | P = 0.083 |
| Fibrinogen (g* L−1) | 2.2 (2.2–2.3) | 2.4 (2.2–2.5) | 2.4 (2.3–2.4) | 2.4 (2.2–2.4) | P = 0.799 |
| FII, FVII, FX (relative conc.) | 0.69 (0.60–0.80) | 0.73 (0.63–0.82)* | 0.73 (0.63–0.81)* | 0.72 (0.62–0.77)†,‡ | P < 0.001 |
| C-reactive protein (mg* L−1) | ≥1 | ≥1 | ≥1 | ≥1 | NS |
| Adrenaline (pg* mL−1) | 31.2 (22.0–55.6) | 55.3 (29.5–66.5) | 87.5 (59.8–159.4)*,† | 54.0 (37.5–77.8)‡ | P = 0.043 |
| Noradrenaline (pg* mL−1) | 65.8 (54.2–89.6) | 144.8 (110.5–196.7)* | 238.8 (168.2–264.0)*,† | 124.3 (93.2–170,4)* | P < 0.001 |
| Protein C (relative conc.) | 60.7 (56.4–64.5) | 61.1 (48.6–72.3) | 60.2 (51.2–66.7) | 60.0 (46.7–67.7) | P = 0.896 |
| sTM (ng* mL−1) | 1.35 (0.87–1.63) | 1.32 (1.04–1.42) | 0.85 (0.80–1.05) | 0.95 (0.84–1.19) | P = 0.315 |
| Syndecan-1 (ng* mL−1) | 18.1 (15.9–21.3) | 17.4 (12.9–21.7) | 17.4 (12.3–20.8) | 17.4 (12.7–23.0) | P = 0.158 |
| D-dimer (ng* mL−1) | 521 (404–1241) | 627 (484–1483) | 845 (666–2071)* | 895 (845–2248)* | P = 0.010 |
| Functional hemostatic assays: | |||||
| TEG: | |||||
| CK R (min) | 6.7 (5.4–7.1) | 5.6 (4.4–6.2) | 5.2 (4.9–5.6) | 5.3 (5.1–5.8) | P = 0.153 |
| CK angle (°) | 61.2 (58.9–63.6) | 61.1 (59.9–64.7) | 64.1 (61.1–65.8) | 63.4 (61.4–66.0) | P = 0.421 |
| CK MA (mm) | 58.7 (57.7–61.7) | 58.5 (57.1–61.7) | 62.2 (60.3–62.8)*,† | 60.1 (58.0–61.7) | P = 0.015 |
| CK Ly30 (%) | 1.2 (0.4–1.5) | 1.2 (0.4–1.9) | 1.1 (0.5–2.0) | 0.4 (0.2–0.8) | P = 0.095 |
| CKH R (min) | 6.8 (5.9–7.2) | 5.9 (4.5–6.3)* | 5.4 (5.0–6.1)* | 5.5 (4.6–5.7)* | P = 0.040 |
| FF MA (mm) | 15.4 (14.5–16.7) | 16.4 (15.1–17.0) | 16.0 (15.0–16.5) | 16.3 (14.6–17.2) | P = 0.110 |
| Multiplate: | |||||
| TRAP (AUC) | 95.0 (88.5–110.0) | 98.9 (82.1–108.9) | 103.0 (92.7–122.5) | 95.7 (88.1–109.6) | P = 0.315 |
| ADP (AUC) | 71.6 (59.1–77.0) | 62.6 (55.3–69.1) | 72.6 (57.7–85.1) | 66.1 (56.2–69.3) | P = 0.066 |
| COL (AUC) | 73.1 (66.2–91.6) | 74.0 (68.5–80.6) | 75.7 (70.7–83.5) | 74.9 (70.9–82.0) | P = 0.591 |
| ASPI (AUC) | 81.3 (62.7–99.8) | 70.8 (64.4–79.4) | 82.2 (63.6–87.5) | 78.6 (68.5–87.7) | P = 0.178 |
FII, coagulation factor II; FVII, coagulation factor VII; FX, coagulation factor X; Ly30, clot lysis 30 min after MA; TRAP, thrombin-receptor activating peptide; ADP, adenosine 5′-diphosphate; COL, collagen; ASPI, arachidonic acid.
Data are shown as median (IQR).
1
Friedman, repeated measures.
*
P < 0.05 versus base line.
†
P < 0.05 versus heat stress.
‡
P < 0.05 versus LBNP (Wilcoxon signed rank post hoc test).