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Monoacylglycerol lipase inhibition can reduce IOP. (A) Topical WIN55212 (1%) reduces IOP in MAGL−/− eyes. (B) 2-Arachidonoyl glycerol (2 mM) treatment in MAGL−/− eyes results in a trend toward IOP reduction (P = 0.0502). (C–E) Topical treatment with KML29 (1 mM) lowers IOP at 1, 4, and 8 hours after treatment. (F) However, KML29 is without effect in CB1−/− mice. *P < 0.05, ϕP = 0.05, paired t-test.
