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. 2016 Jun 29;57(7):3496–3508. doi: 10.1167/iovs.15-18775

Figure 1.

Figure 1

Streptozotocin-injected Nyxnob mice are hyperglycemic. (A) Schematic illustrating the time course of STZ injections and ERG testing paradigms for Nyxnob mice. Both males and females were utilized. (B) Body weight was measured at baseline and at the time of each testing period (n ≥ 5). (C) Systemic nonfasting blood glucose levels were measured at each time point. Values ≥250 mg/dL were considered diabetic (n ≥ 3). (D) Top: representative Western blot analysis of retinal lysates from STZ and CNTL mice at each time point. Bottom: quantification of Kir4.1 levels relative to GAPDH (n ≥ 2 for each group). For all panels, data points indicate the average ±SEM. *P ≤ 0.05. ***P ≤ 0.0001 between CNTL and STZ by 2-way ANOVA with Tukey's post-hoc analysis.