Figure 4.

Lamina cribrosa BD and PD. Within each LC 3D HMRN reconstruction, beam voxels are segmented (shown within a single section image in A and magnified in B). All beam voxels are identified as connective tissue (one representative beam voxel is represented by a green dot in C). All remaining voxels are “pore” voxels (one representative pore voxel is represented by a purple dot in C). Each beam or pore voxel is assigned a BD or PD, which is the diameter of the largest sphere that contains that voxel and fits into either the beam or pore in which it sits (D). Beam diameter or PD for a given beam or region is defined by the population of BD or PD of the constituent voxels.