Figure 4.

(a) Graphs of R(t) (red) and P(t) (blue), normalized with respect to their baseline values R ₀ and P ₀, of the system (Eqs. 15 and 16) for system parameters k_s = 26 ng ⋅ mL⁻¹ h⁻¹, $k_r=0.091$ and k_el = 2.2, h⁻¹ and pharmacokinetic (PK) data S_max = 66 and $S{C}_{50}=22,\hspace{0.17em}C(t)=D\times e^{-k_{a}t}$ for D = 3, $k_a=0.2$ h⁻¹ ( $R_0=12$ and $P_0=286$ ng ⋅ mL⁻¹). (b) The same simulation plotted in the phase plane (MATLAB model code provided in Supplementary Figure S4).