Figure 8.

Simulations of the positive feedback model (Eqs. 23 and 24) without the if condition (a and b) and with the if condition (Eqs. 31 and 32) (c and d) for different doses D of risperidone: $D=0.05,0.1,1$ and 2 mg/kg. The drug pharmacokinetic (PK) is simulated using the PK model for s.c. dose of risperidone.24 (a and c) Dynamics of v vs. time. (b and d) Orbits of u and v plotted in the respective phase planes (MATLAB model code provided in Supplementary Figure S8).