Fig. 4.

Detection of Insulin and c-peptide in the culture supernatant. (A) Undifferentiated UCMSCs release insulin differently in response to low glucose and high glucose concentrations. (B) Differentiated pancreatic progenitor cells release insulin under high glucose insult. (C) Comparative analysis of the insulin released by the two cell types under low glucose and high glucose concentrations. The difference between the insulin released by undifferentiated UCMSCs and the pancreatic progenitors (PP) is statistically significant (p value<0.005). (D) Differentiated pancreatic progenitor cells release c-peptide. (E) High c-peptide released by pancreatic progenitor cells under high glucose conditions.