PTMs cluster in subunits IV, Va, and Vb. PTMs found in bovine CcO (above the bar) in this study (filled symbols) with those reported previously (open symbols) are indicated by squares. PTMs identified in both this and previous studies are transparent. Phosphorylation (red) and acetylation (blue) sites are shown. A comparison between the bovine sites (squares, on top) and those in other mammalia (rat/human/mouse, circles, below the bar) shows that mostly acetylation sites are conserved across the species (filled, transparent circles). The mitochondrial transit peptide is shown in gray.