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(A) Data from cBio portal (www.cbioportal.org) demonstrating PPARG gene amplification or its up-regulated mRNA expression was found in 26% of castrate-resistant CaP specimens, with up-regulation of one or more of the lipid synthesis genes (FASN, ACC, ACLY). (B and C) Consistent with our data, Kaplan–Meier of MSKCC data demonstrating decreased of disease specific survival if one or more of these lipid synthesis genes are up-regulated (P = 0.0181).
