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Computational Mutation Scanning versus Experimental Point Mutations in Fungal Endoglucanase 5A
| Mutations | Stabilizinga | Destabilizinga | Total |
|---|---|---|---|
| True predictionsb | 12 (35%) | 230 (99.6%) | 242 |
| False predictionsb | 22 (65%) | 1 (0.4%) | 23 |
| Total | 34 | 231 | 265 |
Mutations were experimentally assayed by heat inactivation (Trudeau et al., 2014; raw data kindly provided by D. Trudeau).
Mutations were predicted as stabilizing if they exhibited ΔΔGcalc<−0.45 R.e.u. and destabilizing otherwise.
