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. 2016 Jul 26;12(7):e1005749. doi: 10.1371/journal.ppat.1005749

Fig 5. CD103+ cDCs are the main IFN-I producing cells in response to Histoplasma infection.

Fig 5

(A, B) wild-type mice were treated with either rat IgG (control) or α-pDCA1 (pDC depletion) one day before infection and then at 1, 3, 5, 6 dpi. Mice were either mock-infected or infected with 3x105 Histoplasma yeasts. (C, D) WT, Batf3-/-, or TLR7/9-/- mice were infected with 3x105 Histoplasma cells. Lungs were collected at 7 dpi and (A, C) total IFN-I was measured with ISRE reporter cells and (B, D) CFUs were enumerated. Each circle represents a single mouse. All results are representative of two experiments. *p<0.05; **p<0.001; p values were determined by ANOVA.