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Conditions: acetal 1A (0.1 mmol), alkyne 2 (1.5 equiv), MgBr2·OEt2 (1.2 equiv), K2CO3 (1.0 equiv), CHCl3 (0.5 mL, 0.2 M), 60 °C, 24 h. Average isolated yields from duplicate experiments (±4%). E:Z ratios of isolated product mixtures determined by 1H NMR spectroscopy. a 0.2 mmol scale. b 3.0 equiv 2e, CHCl3 (0.1 M). Result of a single experiment.
