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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Curr Pharm Des. 2016;22(14):2152–2159. doi: 10.2174/1381612822666160127114237

Figure 6. Lynx1 expression and function in lung cancers cells.

Figure 6

A. Relative RNA levels of Lynx1 in squamous cell carcinomas compared to normal and also plotted according to degree of differentiation. †p < 0.03 by t-test, *p < 0.05 compared to normal tissue by Tukey-Kramer after One-way ANOVA. Number of samples of each grade is shown in figure legend in parentheses. Figure modified after Song et al [13]. B. siRNA knockdown of lynx1 increased cell growth of A549 lung adenocarcinoma cells. Levels of lynx1 were decreased by ~70% by the siRNA knockdown (data not shown). Data are mean ± SD of 20 replicates in two separate experiments. * p < 0.05 versus control siRNA. C. Effect of increased lynx1 expression in A549 cells. A lentivirus expressing lynx1 was prepared and A549 cells transduced with the lynx-1 lentiviral vector or a control lentivirus. Lynx1 protein expression was highly expressed after transduction (data not shown). Cell growth is shown relative to day 0. * p < 0.05 compared to controls. From Fu et al [76].