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. 2016 Jul 26;11(7):e0159177. doi: 10.1371/journal.pone.0159177

Fig 6. Differential gene expression and statistically significant networks.

Fig 6

A) Heat map display of the strongest, differentially expressed genes measured in HPS-1 HuMCs compared with normal HuMCs; B) Heat map display of mock transduced (control) versus HPS1 transduced HPM cells showing significant differentially expressed and enriched genes; C) FN-1 is a master regulator of amyloid precursor protein APP, CASP7, CD79A and ZBTB7A. Target molecules in the dataset found for APP were CTSB, CTSV, IL-1A and IL-6; D) Central to the FN-1 and APP relationship (left-sided diagram) is a network that in its turn targets the IL-6 network (right-sided diagram), all of which are significantly upregulated. Genes are represented in the nodes and gene-gene relationships in the edges. The intensity/color is a measure of the extent of differential expression. The shapes of nodes represent categories of gene function; FN-1 is an enzyme and shown as a diamond, IL-6 is a cytokine and shown as a square. IL-6 operates in the context of KIT, STAT3, SOCS1, GATA3 and CAMP.