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. 2016 Jul 26;11(7):e0159844. doi: 10.1371/journal.pone.0159844

Fig 8. Proposed model for the dual role of CysK in UPEC536 mediated CDI.

Fig 8

The left panel shows CysK mediated toxin activation in target cell where CysK dimer binds CdiA-CT and activates tRNAase activity causing growth arrest [23]. The right panel shows the moonlighting role of CysK as a modulator of CdiA-CT (M)/CdiI in the CDI+ inhibitory cells, as proposed in the present study. Binding of CysK to CdiA-CT stabilizes CdiA-CT/CdiI immunity complex, primarily by decreasing dissociation rate, to prevent autoinhibition in UPEC536 inhibitor cells.