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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Jun 29;1860(10):2107–2121. doi: 10.1016/j.bbagen.2016.06.022

Fig.8.

Fig.8

Curcumin and PKC signaling pathway in colon cancer. Curcumin suppresses the activity of PKC subsequently affecting MAPK and C-jun. The down-stream effects of PKC include inhibition of UGT, ERK pathway and EGFR affecting the transcription factors and regulators AP-1, NF-kB and ERG-1. UGT, UDP-glucuronosyltransferase; ERK, Extracellular signal-regulated kinase; EGFR, Epidermal growth factor receptor; MAPK, Mitogen activated protein kinase; AP-1, Activated protein-1; EGR, Early growth response.