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Effect of resveratrol on various PKC-mediated biological responses. Resveratrol suppresses the activity of kinases such as protein kinase C (PKC), mitogen-activated protein kinases (MAPK) and IκB kinase (IKK) and transcription factors such as hypoxia-inducible factor-1α (HIF-1α), signal transducer and activator of transcription 3 (STAT3), nuclear factor κB (NF-κB) and activator protein-1 (AP-1) leading to various conditions in response to oncogenic stimuli.
