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. 2016 Mar 28;19(5):451–458. doi: 10.1111/ner.12406

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© 2016 The Authors. Neuromodulation: Technology at the Neural Interface published by Wiley Periodicals, Inc. on behalf of International Neuromodulation Society.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Morphology of microglia. a. The normal or “ramified/quiescent” state of microglia, with branching processes is showed. b. Shows a mildly activated state of microglia, where the processes are beginning to retract. c. Shows activated or “amoeboid” microglia, where processes are almost completely retracted and the cell bodies are round and macrophage‐like. d. Morphometric quantification of the number of Iba1 positive cells in the STN of HFS animals compared to microlesion and sham animals and is representative of the quantitative difference (p = 0.0026) between normal and activated microglia in animals that underwent HFS‐DBS and sham animals as well as animals that underwent microlesioning.