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. Author manuscript; available in PMC: 2017 Jan 21.
Published in final edited form as: Nature. 2016 Jul 21;535(7612):425–429. doi: 10.1038/nature18626

Extended Data Figure 10. IFN-γ increased the number of c-fos+ cells in Layer I of the PFC.

Extended Data Figure 10

a, IFN-γ was injected into the CSF (i.c.m.) 2 hours prior to sacrificing and processing brains for immunohistochemistry. Slices were stained for c-fos. Atlas image adapted from: c 2015 Allen Institute for Brain Science. Allen Brain Atlas [Internet]. Available from: http://www.brain-map.org. b, Total c-fos+ cells in layer I of the PFC (n = 3 mice per group; * P < 0.05). Holding current pre and post IFN-γ application on acute slices from the PFC (c) and somatosensory cortex (d; n = 6 neurons from 3 mice). c, VgatCre::Ifngr1fl/fl mice. IFN-γ increased tonic inhibition in Cre- mice (n = 6–7 cells from 4 mice per group; ** P < 0.01 Sidak’s post-hoc test).