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Ki-values of known CB1/CB2 ligands (entry 1–3; Showalter et al., 1996; Lan et al., 1999; Valenzano et al., 2005) and newly synthesized compounds (entry 4, 5).
| Ki (hCB2) [nM] | Ki (hCB1) [nM] | clogP | |
|---|---|---|---|
| 1. CP-55940 | 0.7 ± 0.02 | 0.6 ± 0.1 | 5.82 |
| 2. AM251 | 2290 ± 900 | 7.5 ± 1.1 | 5.62 |
| 3. GW405833 | 3.9 ± 1.6 | 4772 ± 1676 | 6.90 |
| 4. AAT-778 | 4.3 ± 0.7 | 1100 ± 100 | 6.00 |
| 5. AAT-015 | 3.3 ± 0.5 | 1000 ± 200 | 4.11 |
