. 2015 Dec 3;51:27–47. doi: 10.1007/s12016-015-8522-7

Table 1.

Characteristic of selected mouse models of arthritis

Arthritis model	Feature	Bone erosion		Irreversible cartilage surface erosion		Inflammation					Auto-antibodies		References
Arthritis model	Feature	Bone erosion		Irreversible cartilage surface erosion		Th cells	Cytokines			IC mediated	Auto-antibodies		References
Cartilage directed autoimmunity
Collagen-induced arthritis (CIA)	CII autoimmune	+	+		+		+		+		CII	[53, 54]
Infectious agents/exogenous triggers
Streptococcal cell wall (SCW)	Acute	Peptidoglycan-polysaccharide	−		−		−		+		−	[55]
Streptococcal cell wall (SCW)	Reactivation	Peptidoglycan-polysaccharide	+		+/−		+		+		+/−	[55]
SCW-flare	Memory T cells	+	+/−		+		+		−			[56]
Antigen-induced arthritis (AIA)	Persistent antigen	+	+/−		+		+		+		−	[57]
AIA	Persistent antigen	+	−		+		+		−		−	[58]
AIA-flare	Memory T cells	+	+/−		+		+		−			[59]
Transgenic spontaneous models
K/BxN	GPI, T cell defect	+	+		+			+	+		GPI	[60]
SKG	ZAP-70, T cell defect	+?	?		+			+	−			[61]
Gp130	STAT3, T cell defect	+?	?		+			+	−			[62]
IL-1Ra^−/−	Autoimmune T cells	+	+		+			+	-		−	[63]
hTNF.tg	TNF overexpression	+	+		−			+	−			[64]
BXD2	T cell senescence	+	+		+			+	+			[65, 66]
DNA II^−/−IFN-IR^−/−	DNA clearance	+	+		+?			+	+		CCP and RF	[67]

CII collagen type II, GPI glucose-6-phosphatase isomerase, IC immune complexes, CCP cyclic citrullinated peptide, RF rheumatoid factor