. 2016 Jul 27;36(30):7877–7885. doi: 10.1523/JNEUROSCI.4122-15.2016

Table 1.

Arterial partial pressure of carbon dioxide (PaCO₂) and oxygen (PaO₂), mean arterial pressure (MAP), and base excess during baseline, hypoxia, and 60 min after hypoxia^a

Treatment groups	PaCO₂ (mmHg)			PaO₂ (mmHg)			MAP (mmHg)			Base excess (mEq/L)
Treatment groups	Baseline	Hypoxia	60 min	Baseline	Hypoxia	60 min	Baseline	Hypoxia	60 min	Baseline	Hypoxia	60 min
mASH
Vehicle	46.0 ± 1.1^*	46.2 ± 1.1	45.9 ± 1.2	313 ± 9	46.2 ± 1^**,^†,^††	294 ± 8^**	108 ± 4	81 ± 6^**	100 ± 4^**	−0.2 ± 0.6	−0.6 ± 0.6	1.2 ± 0.5
MSX-3	48.6 ± 0.9	48.8 ± 1.0	49.2 ± 0.9	313 ± 5	44.5 ± 1^**,^†,^††	295 ± 5^**	118 ± 9	77 ± 8^**	106 ± 7^**	−0.4 ± 0.5	−1.3 ± 0.5	0.7 ± 0.5
Methy	46.0 ± 1.3	45.7 ± 1.2	46.4 ± 1.3	295 ± 6	44.7 ± 1^**,^†,^††	263 ± 11^**	106 ± 4	66 ± 4^**	91 ± 3^**	−1.0 ± 0.5	−1.5 ± 0.5	0.0 ± 0.5
Methy + MSX-3	46.3 ± 0.5	47.0 ± 0.6	46.4 ± 0.7	290 ± 12^*,^†††	45.4 ± 2^**,^†,^††	278 ± 10	97 ± 8^*	68 ± 7^**	94 ± 5	0.3 ± 0.7	−0.3 ± 1.0	1.6 ± 1.0
sASH
Vehicle	45.7 ± 0.9^*	44.2 ± 0.8^**	46.4 ± 0.8	310 ± 5	30.4 ± 1^,^*,^††	291 ± 9^**	110 ± 8	52 ± 9^**	94 ± 9^**	−0.9 ± 0.5	−8.9 ± 1.6^**	0.9 ± 1.0
MSX-3	46.9 ± 1.0	46.7 ± 0.9	47.0 ± 0.9	309 ± 4	31.8 ± 1^,^*,^††	291 ± 6^**	106 ± 6	49 ± 5^**	83 ± 5^**	−0.2 ± 0.3	−7.1 ± 1.1^**	−0.1 ± 0.4
Methy	48.1 ± 1.3	48.2 ± 1.0	48.5 ± 1.3	262 ± 13^‡	30.3 ± 1^,^*,^††	238 ± 9^**	99 ± 6	40 ± 5^**	91 ± 5	1.0 ± 0.5	−8.4 ± 0.9^**	−0.5 ± 1.2
Time control
Vehicle	46.0 ± 0.9	46.1 ± 0.8	45.3 ± 0.8	311 ± 10	310 ± 8	301 ± 7	101 ± 7^*	99 ± 7	93 ± 7	−0.1 ± 0.7	0.0 ± 0.6	1.1 ± 0.6
MSX-3	48.3 ± 0.4	48.5 ± 0.5	48.9 ± 0.5	310 ± 7	306 ± 6	304 ± 8	112 ± 4	109 ± 4	100 ± 5^**	0.5 ± 0.6	1.1 ± 0.3	2.5 ± 0.4
Methy	47.0 ± 0.9	47.1 ± 1.0	46.9 ± 0.8	299 ± 9	299 ± 11	276 ± 9^**	103 ± 6	101 ± 6	104 ± 8	−0.2 ± 0.4	0.1 ± 0.4	1.1 ± 0.2

^aValues are mean ± SE.

Significant difference (p < 0.05) from MSX3 + mASH (*), baseline (**), all mASH groups (***), all sASH groups (†), all time control groups (††), vehicle + mASH (†††), or all groups (‡).