Table 1.
Treatment groups | PaCO2 (mmHg) |
PaO2 (mmHg) |
MAP (mmHg) |
Base excess (mEq/L) |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | Hypoxia | 60 min | Baseline | Hypoxia | 60 min | Baseline | Hypoxia | 60 min | Baseline | Hypoxia | 60 min | |
mASH | ||||||||||||
Vehicle | 46.0 ± 1.1* | 46.2 ± 1.1 | 45.9 ± 1.2 | 313 ± 9 | 46.2 ± 1**,†,†† | 294 ± 8** | 108 ± 4 | 81 ± 6** | 100 ± 4** | −0.2 ± 0.6 | −0.6 ± 0.6 | 1.2 ± 0.5 |
MSX-3 | 48.6 ± 0.9 | 48.8 ± 1.0 | 49.2 ± 0.9 | 313 ± 5 | 44.5 ± 1**,†,†† | 295 ± 5** | 118 ± 9 | 77 ± 8** | 106 ± 7** | −0.4 ± 0.5 | −1.3 ± 0.5 | 0.7 ± 0.5 |
Methy | 46.0 ± 1.3 | 45.7 ± 1.2 | 46.4 ± 1.3 | 295 ± 6 | 44.7 ± 1**,†,†† | 263 ± 11** | 106 ± 4 | 66 ± 4** | 91 ± 3** | −1.0 ± 0.5 | −1.5 ± 0.5 | 0.0 ± 0.5 |
Methy + MSX-3 | 46.3 ± 0.5 | 47.0 ± 0.6 | 46.4 ± 0.7 | 290 ± 12*,††† | 45.4 ± 2**,†,†† | 278 ± 10 | 97 ± 8* | 68 ± 7** | 94 ± 5 | 0.3 ± 0.7 | −0.3 ± 1.0 | 1.6 ± 1.0 |
sASH | ||||||||||||
Vehicle | 45.7 ± 0.9* | 44.2 ± 0.8** | 46.4 ± 0.8 | 310 ± 5 | 30.4 ± 1**,***,†† | 291 ± 9** | 110 ± 8 | 52 ± 9** | 94 ± 9** | −0.9 ± 0.5 | −8.9 ± 1.6** | 0.9 ± 1.0 |
MSX-3 | 46.9 ± 1.0 | 46.7 ± 0.9 | 47.0 ± 0.9 | 309 ± 4 | 31.8 ± 1**,***,†† | 291 ± 6** | 106 ± 6 | 49 ± 5** | 83 ± 5** | −0.2 ± 0.3 | −7.1 ± 1.1** | −0.1 ± 0.4 |
Methy | 48.1 ± 1.3 | 48.2 ± 1.0 | 48.5 ± 1.3 | 262 ± 13‡ | 30.3 ± 1**,***,†† | 238 ± 9** | 99 ± 6 | 40 ± 5** | 91 ± 5 | 1.0 ± 0.5 | −8.4 ± 0.9** | −0.5 ± 1.2 |
Time control | ||||||||||||
Vehicle | 46.0 ± 0.9 | 46.1 ± 0.8 | 45.3 ± 0.8 | 311 ± 10 | 310 ± 8 | 301 ± 7 | 101 ± 7* | 99 ± 7 | 93 ± 7 | −0.1 ± 0.7 | 0.0 ± 0.6 | 1.1 ± 0.6 |
MSX-3 | 48.3 ± 0.4 | 48.5 ± 0.5 | 48.9 ± 0.5 | 310 ± 7 | 306 ± 6 | 304 ± 8 | 112 ± 4 | 109 ± 4 | 100 ± 5** | 0.5 ± 0.6 | 1.1 ± 0.3 | 2.5 ± 0.4 |
Methy | 47.0 ± 0.9 | 47.1 ± 1.0 | 46.9 ± 0.8 | 299 ± 9 | 299 ± 11 | 276 ± 9** | 103 ± 6 | 101 ± 6 | 104 ± 8 | −0.2 ± 0.4 | 0.1 ± 0.4 | 1.1 ± 0.2 |
aValues are mean ± SE.
Significant difference (p < 0.05) from MSX3 + mASH (*), baseline (**), all mASH groups (***), all sASH groups (†), all time control groups (††), vehicle + mASH (†††), or all groups (‡).