Figure 7.

Expression of mGluR-nLTP requires mGluR1 and mGluR5 activity. Recordings were performed with a Cs-based internal solution. A, mGluR-nLTP was reversed following bath application of CPCCOEt (100 μm, n = 5), which began 20 min after start of DHPG application. B, mGluR-nLTP was reversed following bath application of MPEP (50 μm, n = 5), which began 20 min after start of DHPG application. A, B, Left, Representative traces recorded in control (black), 20 min following start of DHPG application (blue), and 10 min following start of mGluR antagonist application (red). A, B, Middle, Representative experiments show time course of mGluR-nLTP before and following mGluR antagonist application. Individual values indicate average over 5 consecutive time points. *Time points of recordings shown on left. A, B, Right, Summary data, expressed as mean ± SEM.