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. 2016 Jul 13;2016:9345495. doi: 10.1155/2016/9345495

Figure 2.

Figure 2

Effect of OPN fragments on cytokine secretion. (a) IFN-γ, (b) IL-17A, and (c) IL-10 protein evaluated in the culture supernatants from CD4+ T cells by ELISA or (d) by intracellular staining with anti-IL-17A and anti-IL-10 after 5 days of treatment with OPN variants. (e) IL-6 and (f) TIMP-1 protein secreted by monocytes after 2 days of treatment with OPN variants. Data are expressed as the mean ± SE from 6 independent experiments (∗ p < 0.05; ∗∗ p ≤ 0.01 versus the control; § p < 0.05; §§ p ≤ 0.01 versus OPN-FL; # p < 0.05; ## p ≤ 0.01 versus OPN-C; Wilcoxon's signed rank test).