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. 2016 Jul 22;7:12200. doi: 10.1038/ncomms12200

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Schematic model of target mRNA-driven miRNA biogenesis. Immediately after pre-miRNA processing and AGO2 loading, DICER1 remains associated with AGO2. Newly formed miRISC/DICER1 complex scans the 3′-UTR of a mRNA in search of cognate miRNA-binding site. On target site finding and miRNA–mRNA hybrid formation, DICER1 dissociates from AGO2 and binds free AGO2 to catalyse another round of pre-miRNA processing and miRNP formation. The presence of the target sites increases the ‘processivity' of DICER1, leading to enhanced miRNA biogenesis from precursor per unit time.