Table 2. Genes Implicated in RLS and PLMS: Cohort, Location, and Function.
| Gene | Chromosome | Function | SNP | Cohort |
|---|---|---|---|---|
| BTBD9 | 6p21.2 | Synaptic plasticity, learning | rs3923809, rs9296249, rs9357271 | Iceland,103 United States,106 Germany,104 Austria,114 Canada,104 Czech Republic,114 Finland,114 Korea115 |
| MEIS1 | 2p14 | Homeobox gene, limb formation, motor neuron connectivity | Rs2300478 | Germany,104 Austria,114 Czech Republic,114 Canada,104 United States106 |
| PTPRD | 9p23-24 | Protein tyrosine phosphatase regulates cell growth, mitosis | rs4626664, rs1975197 | Korea,115 United States116 |
| MAP2K5 | 15q23 | Protein kinase involved in cell proliferation | Rs12593813, rs11635424, rs4489954, rs3784709, rs1026732, rs6494696 | Germany,104 Austria,114 Czech Republic,114 Canada,104 United States106 |
| TOX3 | 16q12.1 | Transcription factor | Rs3104767, rs3104788 | Germany117 |
Abbreviations: PLMS, Periodic Limb Movements during Sleep; RLS, Restless Legs Syndrome; SNP, Single Nucleotide Polymorphism.