Table 3.
Influence of 7-day intragastric administration of zinc asparaginate on toxic element content in rat organs (μg/g).
| Element | Control | ZnA5 | ZnA15 | p-value |
|---|---|---|---|---|
| Liver Al | 0.967 (0.922–1.917) | 0.800 (0.555–1.384) | 0.320 (0.289–0.411) 1 | 0.018* |
| Liver As | 0.127 (0.108–0.150) | 0.147 (0.136–0.159) | 0.143 (0.136–0.163) | 0.368 |
| Liver Li | 0.005 (0.004–0.005) | 0.004 (0.004–0.004) | 0.005 (0.004–0.005) | 0.281 |
| Liver Ni | 0.019 (0.017–0.021) | 0.014 (0.013–0.020) | 0.007 (0.006–0.009) 1 | 0.049* |
| Liver Pb | 0.003 (0.002–0.003) | 0.004 (0.003–0.007) | 0.005 (0.004–0.006) 1 | 0.055 |
| Liver Sn | 0.011 (0.004–0.025) | 0.005 (0.004–0.022) | 0.002 (0.001–0.003) 1,2 | 0.003* |
| Liver Sr | 0.042 (0.039–0.045) | 0.063 (0.040–0.069) | 0.039 (0.038–0.043) | 0.140 |
| Kidney Al | 0.423 (0.399–0.505) | 0.309 (0.246–.375) | 0.478 (0.351–0.968) | 0.117 |
| Kidney As | 0.061 (0.061–0.065) | 0.073 (0.061–0.081) | 0.070 (0.064–0.078) | 0.098 |
| Kidney Li | 0.005 (0.004–0.005) | 0.003 (0.003–0.004) 1 | 0.011 (0.009–0.011) 1,2 | 0.001* |
| Kidney Ni | 0.037 (0.032–0.041) | 0.025 (0.021–0.026) 1 | 0.027 (0.022–0.034) 1 | 0.013* |
| Kidney Pb | 0.004 (0.002–0.008) | 0.004 (0.003–0.004) | 0.006 (0.005–0.009) | 0.172 |
| Kidney Sn | 0.002 (0.002–0.003) | 0.002 (0.001–0.008) | 0.003 (0.002–0.003) | 0.907 |
| Kidney Sr | 0.094 (0.087–0.104) | 0.087 (0.084–0.094) | 0.089 (0.086–0.100) | 0.796 |
| Heart Al | 0.410 (0.395–0.571) | 0.586 (0.491–0.721) | 0.392 (0.341–0.674) | 0.700 |
| Heart As | 0.065 (0.061–0.078) | 0.056 (0.044–0.067) | 0.061 (0.056–0.065) | 0.281 |
| Heart Li | 0.003 (0.003–0.004) | 0.003 (0.003–0.004) | 0.007 (0.007–0.007) 1,2 | 0.003* |
| Heart Ni | 0.025 (0.020–0.026) | 0.012 (0.010–0.014) 1 | 0.012 (0.011–0.013) 1 | 0.025* |
| Heart Pb | 0.004 (0.003–0.005) | 0.004 (0.003–0.004) | 0.007 (0.005–0.008) 2 | 0.031* |
| Heart Sn | 0.004 (0.002–0.011) | 0.003 (0.003–0.004) | 0.002 (0.002–0.002) | 0.078 |
| Heart Sr | 0.060 (0.058–0.069) | 0.051 (0.045–0.055) | 0.045 (0.043–0.051) 1 | 0.011* |
Data expressed as Median(25–75)
– Significant difference in comparison to Control (I) animals (p<0.05)
– Significant difference in comparison to ZnA5 (II) animals (p<0.05)
- p-trend is significant at p-values <0.05.