Table 1.
Frequencies (Mean±SE) of micronucleated erythrocytes (% MNEs) and mitotic activity (% PCE) in bone marrow of mice exposed to aqueous extracts of Spondias mombin (ASM), Nymphaea lotus (ANL) and Lufffa cylindrica (ALC) alone and with methyl methane sulfonate
| Conc. (mg/kg) | MNPCE | ASM % Amelioration | % PCE | MNPCE | ANL % Amelioration | % PCE | MNPCE | ALC % Amelioration | % PCE |
|---|---|---|---|---|---|---|---|---|---|
| DDW | 4.8±0.8 | 61.4±1.8 | 4.8±0.8 | 61.4±1.8 | 4.8±0.8 | 61.4±1.8 | |||
| 200 | 10.0±0.4†† | 54.2±1.2† | 8.3±2.9†† | 68.5±0.7† | 12.8±1.6†† | 49.2±5.4† | |||
| 400 | 2.5±1.0 | 54.6±0.8† | 11.0±2.3†† | 59.3±4.2 | 9.3±1.5†† | 59.5±0.8† | |||
| 800 | 5.5±1.2† | 51.8±0.2†† | 8.5±1.2†† | 59.3±0.3 | 18.7±5.5†† | 54.5±3.1 | |||
| 1600 | 4.0±1.5 | 52.0±1.8†† | 13.3±0.3†† | 55.7±1.4 | 29.0±3.0†† | 58.1 ±0.9 | |||
| MMS | 28.0±3.1†† | 46.3±0.6†† | 28.0±3.1††** | 46.3±0.6 | 28.0±3.1†† | 46.3±0.6†† | |||
| 200+MMS | 12.0±0.4††** | 55.6 | 57.7±1.5** | 16.3±2.8††** | 42.0 | 54.0±0.5††* | 20.5±1.3††* | 23.8 | 60.4±0.2** |
| 400+MMS | 6.5±1.2††** | 75.0 | 59.4±1.7** | 12.0±3.2††** | 57.1 | 54.9±1.7†** | 7.3±1.6†** | 74.1 | 55.9±1.2* |
| 800+MMS | 7.0±1.8††** | 73.1 | 57.4±0.5** | 7.3±1.1†† | 74.1 | 60.7±0.3** | 6.0±1.7†** | 77.4 | 59.1±1.6** |
| 1600+MMS | 4.3±1.0** | 83.7 | 40.0±3.4†* | 10.7±2.7††** | 61.9 | 50.1±3.2††* | 17.5±0.5††** | 32.7 | 50.7±2.3† |
All the groups were compared with the negative control. The antigenotoxic groups were also compared with MMS. Significant difference from distilled water group
†
-(p<0.05)
††
-(p<0.01); Significant difference from MMS
*
*-(p<0.05)
**
-(p<0.01); DDW-distilled water; MMS-methyl methane sulfonate (60 mg/kg); MNPCE-micronucleated polychromatic erythrocyte; PCE-polychromatic erythrocyte.