Figure 2. Effect of RNaseH1 knockdown for GR gapmer-derived hepatotoxicity.

Mice were administrated an siRNA–invivofectamine complex 2 days prior to s.c. injection of 10 mg/kg gapmer. Plasma was collected 4, 7 and 10 days later, and mouse liver was isolated on day 10. (a) Plasma ALT level; (b) plasma AST level; (c) Expression level of RnaseH1 and (d) GR mRNA in liver (n = 4, mean ± S.D., *p < 0.05, Mann–Whitney U test, vs saline + gapmer).